Maksutova NN, Shamansurova ZM, Akbarov ZS.
Institute of Endocrinology, Tashkent 700143, UZBEKISTAN

Background and aim. Diabetes Mellitus (DM) and Grave’s disease (GD) all has similar autoimmune mechanisms and accompany with eye damage. There little investigation devoted to frequency eye damage when GD combined with (DM). 
Materials and Methods. 82 patients with DM with GD, 30 patients with GD and 64 with DM were observed by direct ophthalmoscopy with pupil dilatation. 

Results:
Diabetic retinopathy (DR) registered in 73.4% cases in DM group and 53.7% cases in DM with GD group. Where non-prolipherative DR1 detected in 44.7% and preprolipherative DR2 in 48.9% and prolipherative DR3 in 8.51% cases among DM patients. In DM with GD patients DR1 registered in 68.2%, DR2 in 25% and DR3 in 6.8% cases. Analysis of data according to duration of DM show that DR frequency at the 0-5 years was 39.1% and 32.6% cases, 5-10 years 87% and 66.7%, after 10 years 100% and 87.4% in DM and DM with GD group respectively. Grave’s ophthalmopathy (GO) frequencies registered in 38.5% cases at the GD and in 37.8% cases at the GD with DM. In DM with GD group GO without retinopathy were detected in 46.3% and retinopathy without GO were detected in 62.2% patients. 

Conclusion:
Results show that DR frequencies were higher and DR degree was more serious in DM patients than DM with GD. GO frequencies not difference when GD combined with DM.