Editor
in Chief :
Mahmoud
Ashraf Ibrahim ,MD |
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Current Volume: 1
Current Issue : 1
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Volume
1 number 1 Summer 2003
Special issue for the abstracts of the 7th Pan Arab Conference
on Diabetes
PACD7 , 25 – 28 March 2003 Cairo
Abstract Number : 16
The pattern and determinants of dyslipidaemia in Type 2 diabetes mellitus patients in Kuwait
Afaf Al-Adsani and Anjum Memon, Dr. Anjum Memon MBBS, DPhil.
Associate Professor of Epidemiology
Department of Community Medicine & Behavioral Sciences
Faculty of Medicine, Kuwait University
We conducted a clinical study to assess the pattern of dyslipidaemia in Type 2 diabetic patients and to examine the demographic and clinical factors associated with dyslipidaemia. The study population comprised 206 consecutive Type 2 diabetic patients attending the outpatient clinic at a public hospital in Kuwait. Clinical history and physical examination were done and fasting blood samples were taken to determine HbA1c and lipid levels. American Diabetes Association criteria were applied to define clinical targets for lipid levels and CHD risk categories. Stepwise multiple linear regression was conducted to identify the demographic and clinical factors associated with lipid levels outside of the clinical target. The large majority (89%) of the patients was either overweight (32%) or obese (57%); the mean BMI was 33 kg/m2. Above optimal levels for total cholesterol, LDL-cholesterol, and triglycerides were observed in 67%, 86%, and 25% of subjects, respectively. For HDL-cholesterol, 63% of men and 71% of women had values below the corresponding optimal level. Only 14 (7%) patients had all three-lipid values within the respective target level. The percentages of patients with one, two, or all three-lipid values outside of target were 31, 46, and 16%, respectively. The most frequent (41%) pattern of dyslipidaemia was a combination of a LDL-cholesterol level above target with an HDL-cholesterol level below target; the second most common pattern was an isolated increase in LDL-cholesterol, observed in 21% of the patients. In the stepwise regression analyses, glycaemic control was strongly associated with dyslipidaemia (i.e., high total- and LDL-cholesterol and triglycerides); and female gender with lows HDL-cholesterol. Kuwaiti patients with Type 2 DM have a high prevalence of dyslipidaemia and obesity. Weight reduction, improved glycaemic control, and increasing HDL-cholesterol levels, along with lowering LDL-cholesterol, should be important goals of therapy in these patients to reduce the risk of CHD.
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