Volume 1 number 1 Summer 2003
Special issue for the abstracts of the 7th Pan Arab Conference on Diabetes
PACD7 , 25 – 28 March 2003 Cairo

 Abstract Number : 24
Evaluation of hypoglycemic and anti-hyperglycemic
Activities of flavonoids from Garcinia kola seeds in
Rats.

OA Adaramoye*, 1, EO Adeyemi2, and GO Emerole1
1Department of Biochemistry, University of Ibadan,
Nigeria.
2Department of Internal Medicine, UAE University, Al
Ain, UAE.

ABSTRACT:
Garcinia kola Heckel (family; Guttiferae) and it extracts are widely used in African traditional medicine for the treatment of heartburn, liver disorder, laryngitis and diabetes. The seed was extracted by soxhlet and partitioned with chloroform/water to obtain Kolaviron (KV, a complex biflavonoid) and then separated by thin layer chromatography to fractions. Identities of these fractions were determined by their RF values and 1H NMR data, and identified as Garcinia biflavanone (GB) 1, GB2 and Kolaflavanone (KF). Comparative studies on the hypoglycemic and anti-hyperglycemic effects of KV, GB1, GB2 and KF in normal and Streptozotocin (STZ)-diabetic rats were investigated. In normal rats, KV, GB1and GB2 administered at 100 mg/kg elicited a significant (p<0.05) hypoglycemic activity within 4 h after oral administration. KV, GB1 and GB2 decreased blood glucose levels of rats by 66%, 61% and 50%, respectively over controls within 30 minutes after oral administration. In hyperglycemic rats, only KV, GB1 and GB2 (100-mg/ kg) significantly (p<0.05) reduced the blood sugar levels in STZ- diabetic rats within 4 h of oral administration. Furthermore, only KV (at 100- mg/ kg) produced a significant (p<0.05) anti-diabetic effect from day 3 to 7 of oral intubations of STZ-diabetic rats. In addition, all the extracts showed a favorable effect on the plasma lipid profile of both normal and STZ-diabetic rats. These studies confirm the anti-diabetic property of Garcinia kola seeds and support its use in ethnomedicine for the treatment of diabetics. Key Words: Garcinia kola, diabetics, and flavonoids, Streptozotocin

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