Volume 1 number 1 Summer 2003
Special issue for the abstracts of the 7th Pan Arab Conference on Diabetes
PACD7 , 25 – 28 March 2003 Cairo

 Abstract Number : 26
GLUCOSE TOLERANCE ABNORMALITIES ARE PREDICTED BY THE HIGH FASTING INSULIN-TO-GLUCOSE RATIO IN HIRSUTE WOMEN.

B.Ftouhi, M.Chihaoui, I. Daoud, F.Kanoun, F.Ben Khalifa.
Department of Endocrinology-Diabetology, University Hospital La Rabta, Tunis, Tunisia

BACKGROUND AND AIM: 
It has been noted that glucose tolerance abnormalities are more frequent in hirsute women. The determination of an index predicting further deterioration of glucose tolerance can be of high interest in terms of prevention. So, the aim of the study was to determine whether glucose tolerance abnormalities could be predicted by high fasting insulin-to-glucose ratio (I0/G0) in hirsute women. 

POPULATION AND METHODS:
It is a prospective study including 107 normoglycaemic (NG) women with hirsutism: mean age = 25.5±6.5 years, mean body mass index = 29.1±6.6Kg/m2, mean waist to hip ratio = 0.85±0.10. At baseline, clinical data (weight, height, waist and hip circumferences, systolic and diastolic blood pressure) and metabolic variables (fasting blood glucose, insulin, total cholesterol, triglycerides and HDL cholesterol, and 2 hours after oral glucose load blood glucose and insulin) were determined. The Glycaemic State was determined again at the end of a mean follow-up of 31.7±22.2 months.

RESULTS:
At the end of the follow-up, we noted 78 NG, 23 impaired fasting glucose tolerant (IFGT) ET 6 diabetic subjects. The IFGT and the diabetic ones had at baseline significantly higher body mass index (p<0.05), diastolic blood pressure (p<0.005), two hours blood glucose (p<0.0005), triglycerides (p<0.05), fasting and post load insulin (p<0.0005), and I0/G0 ratio (p<0.0005). The prevalence of IFGT and diabetes increased with I0/G0 ratio quartiles whereas the prevalence of N decreased (p<0.0005). 

CONCLUSION:
I0/G0 ratio could be a high predictive risk factor of deterioration of glucose metabolism in hirsute women.

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