Volume 1 number 1 Summer 2003
Special issue for the abstracts of the 7th Pan Arab Conference on Diabetes
PACD7 , 25 – 28 March 2003 Cairo

Abstract Number : 28
CAN MEDICAMENT THERAPY OF OBESITY TAKE PART IN EDUCATION
OF OBESE DIABETICS

Georgina Pudar and Andrijana Brankovic
University Hospital ”°Zvezdara”±, Dept of Endocrinology, Diabetes and
Metabolic diseases, Belgrade, D.Tucovica 161, Yugoslavia

Beside dietary management and physical activity, effective treatment of obesity also includes drug therapy. Orlistat is a lipase inhibitor, which partially inhibits dietary fat absorption and has been shown to promote weight loss and weight maintenance when combined with behavioral treatment. The present study included 12 obese adult diabetics, 4 ”Ī and 8 ”Ļ (BMI>30 kg/m©÷) followed during 6 months. They were treated with Orlistat 120 mg three times daily with each meal and with a mildly low energy diet (1500 -1800 cal) during first 3 months and only with diet management during the next 3 months. Body weight (TT), body mass index (BMI), and serum levels of glucose, cholesterol and triglycerides at the beginning of the study and after 3 and 6 months follow-up period were determined. Examined diabetics during the period when they were treated with Orlistat achieved a weight loss of 8.71”¾1.84 kg (120.86”¾15.75 vs. 112.14”¾16.32) and they reduced BMI (37.57”¾4.79 vs. 34.85”¾4! .88 kg/m©÷). They also showed the changes in serum levels of glucose (9.88 ”¾ 2,62 vs. 8,42”¾2.94 nmol/l), cholesterol (7.83”¾1.41 vs. 6.73”¾0.87 mmol/l) and triglycerides (4.20”¾ 1.96 vs. 3.32”¾1.53 mmol/l). Medicament therapy with Orlistat had effects on the reduction of body weight, BMI, and serum”Æs glucose and lipids levels. In following three months, patients treated with only diet management continued to lose weight for 5.28”¾2.32 kg (106.86”¾15.63) and to reduce their BMI (33.21”¾ 4.70 kg/m©÷), glucose (7,60+2,44nmol/l), cholesterol (6.31”¾0.80 mmol/l) and triglycerides (2.66”¾1.10 mmol/l). Results of our study showed that medicament therapy used for a short period of time had achieved a significant weight loss (7,2% of body weight). It is possible that medicament therapy can have educative effects and influence on behavior changes, which contribute to further weight loss and better metabolic control.

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