Editor in Chief : Mahmoud Ashraf Ibrahim ,MD

Issues per Volume: Quarterly Current Volume: 1 Current Issue : 1

Volume 1 number 1 Summer 2003
Special issue for the abstracts of the 7th Pan Arab Conference on Diabetes
PACD7 , 25 – 28 March 2003 Cairo

 Abstract Number : 5
Comparison of the effects of castration and streptozotocin-induced diabetes mellitus on contractile responses of the rat seminal vesicle.

Salma A Bukhatwa, Libya

Abstract:
Comparison of the effects of castration and streptozotocin-induced diabetes mellitus on contractile responses of the rat seminal vesicle.
Salma A Bukhatwa¹, Suleiman I Sharif ²
¹ Department of pharmaceutics, Faculty of pharmacy, Garyounis university, Benghazi, Libya
² Department of pharmacology, Faculty of pharmacy, Ajman university, Ajman, UAE

Abstract:
In the rat seminal vesicle, contraction induced by catecholamines has suggested the presence of adrenergic receptors in the membrane. A modification of the rat isolated seminal vesicle preparation is described. Emphasizing the necessity to use animals of 12 weeks old and weighing nearly 250 gm, and the isolated tissues were suspended under a resting tension of 1 gm in a continuous flow of Krebs’ solution, maintained at 37°C, and bubbled with 5% CO2 in O2. 
 Contractile responses of androgen-sensitive smooth muscles such as the seminal vesicles are highly dependent upon the endocrine status of the animal. Diabetes and castration produced a significant decrease in serum testosterone level and seminal vesicles weights. Contractile responses of seminal vesicles from diabetic rats to noradrenaline and phenylephrine were significantly increased while there was no, change in response to tyramine. Responses to nerve stimulation were reduced as compared to control. Similar results were obtained wit