Volume 1 number 1 Summer 2003
Special issue for the abstracts of the 7th Pan Arab Conference on Diabetes
PACD7 , 25 – 28 March 2003 Cairo

Abstract Number : 84
THE TALE OF IMMUNOGENETIC PATHOGENESIS OF DIABETES
BY

HALA EL-SHEREEF
LECTURER OF INTERNAL MEDICINE-ASSIUT UNIVERSITY , Egypt

q  Type 1diabetes
4 phases can be distinguished 

Genetic predisposition 

Environmental factors                                  Autoimmune response 
Beta cell destruction                                    Genetic 

factors: several genes may be involved
* MHC complex :3 classes of genes in this complex 
Type 1 is associated with HLADR3 and HLADR4
HLADR2 protects against type 1. 
* Several other loci with weaker linkage

Environmental factors: 
* Viruses
* Diet 
* Life style
Autoimmune response : leading to production of auto antibodies and 
beta cell destruction .

q  Type 2 diabetes
Is predominantly or perhaps entirely due to genetic factors 
several genes are implicated

q  MODY
Definite gene defects have been identified, all are inherited in an 
autosomal dominant manner 

q  Genetic susceptibility to diabetic complications 
Siblings of probands with diabetic nephropathy show much higher 
incidence of nephropathy compared with probands without 
nephropathy 

q  Genetic counselling 

if the parents have a child with diabetes ,what is the risk in other 
children?
Relatives of individuals with one type of diabetes are not at greater 
risk to develop the other type.

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