Ebers papyrus (c. 1550 BC) contains descriptions of clinical
states of polyuria.
Langerhans – described clusters of cells (islets)
looked like lymph nodes in the pancreas.
Minkowski (1858–1931) – physician and scientist
observed that diabetes could happen when an animal's pancreas
Best ( professor and his student ) and insulin-treated
pancreatectomized dog –obtained and purified islets
of Langerhans from an animal pancreas, injected its material
(insulin) into a diabetic dog , and find a fall in blood
sugar level. They won Nobel prize for this discovery .
University of Toronto, 1922
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