Minkowski (1858–1931) – physician and scientist
observed that diabetes could happen when an animal's pancreas
Best ( professor and his student ) and insulin-treated
pancreatectomized dog –obtained and purified islets
of Langerhans from an animal pancreas, injected its material
(insulin) into a diabetic dog , and find a fall in blood
sugar level. They won Nobel prize for this discovery .
University of Toronto, 1922